Greg Galle sees problems piling up everywhere. Faster than solutions can be generated. Faster than the problems can even be recognized. Galle refers to the margin between emerging challenges and our ability to meet them as “the ingenuity gap,” and he suggests that, to close that gap, we must abandon a series of accepted views that rule our thinking and suppress individual ingenuity. The work of Galle and his think tank, Future Partners, spans an impressive range of areas, including healthcare, education, and economic and community development. This year they aim to transform the clinical trial experience for breakthrough cancer treatments.